Your trusted source for whole person education. This March edition focusing on cardiovascular and endothelial health includes:

• Upcoming live webinars you don't want to miss
• Spotlight on protocols, ingredients, and more

Join us on March 6th at 2 p.m. ET to learn how the Cardio IQ^® Metabolic Risk Panel goes beyond standard lipid testing. Explore how green seaweed extract (Monostroma nitidum) supports glycocalyx integrity and vascular function. Finally, discover how Fullscript’s tools and protocols help you seamlessly integrate evidence-based strategies into your clinical practice.

Join us on March 20th at 2 p.m. ET to learn how to utilize inflammation testing by Quest Diagnostics to assess your patients’ cardiovascular risk through key vascular markers. Explore the cutting-edge role of specialized pro-resolving mediators (SPMs) and their role in promoting a pro-resolution inflammatory response. Finally, discover how Fullscript’s tools and protocols can help you seamlessly integrate evidence-based strategies into your clinical practice.

Evidence shows that 1,800–3,000 mg of combined EPA and DHA daily for 2–6 months can slow atherosclerotic progression and improve endothelial function. (Wang 2012) However, behavior change is challenging, and patient education takes time. Our evidence-based, omega-3 fatty acids patient resources can help simplify complex recommendations.

Emerging research highlights the critical yet often-overlooked link between oral and cardiovascular health. A Japanese case-control study found that Streptococcus anginosus was significantly more abundant in the saliva and gut of stroke patients. S. anginosus was linked to a 20% higher risk of stroke. (Tonomura 2025) A 25-year observational analysis of 6,000 US adults linked flossing to significantly lower risks of ischemic and cardioembolic stroke, as well as atrial fibrillation, independent of brushing and dental visits. (Sen 2025) Though preliminary, these studies reinforce the importance of oral hygiene in supporting cardiovascular health.

Developed in collaboration with OvationLab, this protocol integrates targeted lab testing with evidence-based supplements to support early detection, personalized interventions, and long-term wellness.

A rhamnan sulfate extract from Monostroma nitidum. An in-vitro study found high glucose degraded the endothelial glycocalyx, while MonitumRS™ effectively reversed the damage. (Chinese Academy of Sciences 2023) A six-month case series assessed the effects of daily supplementation in six high-risk patients with carotid atherosclerosis who were unresponsive to prior interventions. Carotid intima-media thickness (CIMT) ultrasound showed a significant reduction in total plaque burden and maximum plaque thickness. These findings suggest MonitumRS™ may support atherosclerotic plaque reduction. (Burke 2023)

SPMs are omega-3-derived lipids that actively resolve inflammation, promoting tissue repair and immune balance. A five-day open-label study involving ten healthy volunteers and ten patients with peripheral artery disease (PAD) found that supplementation increased plasma SPM levels, enhanced leukocyte activity, and shifted monocytes toward an anti-inflammatory state, with the strongest effects in the patients with PAD. These results suggest a potential therapeutic benefit for inflammation resolution in vascular health. (Schaller 2020)

Join world-leading experts in GLP-1 therapy and metabolic health as they explore advanced clinical applications, precision implementation strategies, integrated lifestyle approaches, and practical tools to enhance patient outcomes and metabolic flexibility.

This newsletter is brought to you by Fullscript’s Medical Advisory Team. Have questions? Please email us at education@fullscript.com. Content provided for practitioner information purposes only. Not for distribution.